Background: Ensuring the comfort of the patient during Percutaneous Coronary Interventiıon (PCI) is one of the nursing care goals. During procedure, the patient’s comfort level may vary depending on the vascular access method. Studies examining comfort from a nursing perspective in coronary interventions are very limited. Objective: This study is a descriptive cros-sectional study to identify the general comfort levels of the patients and to determine whether transradial or transfemoral access method affects the comfort level in PCI. Methods: The study was conducted on 200 volunteer patients in a private university hospital in Istanbul between May 2018 and May 2019. General Comfort Questionnaire (GCQ) was used in this study. In the evaluation of the data, t-test as well as percentage, mean, standard deviation, row mean descriptive statistical methods were used. Results: In this study, 46% of the participants were in the 40-59 age group, 47% were over 60 years old, 74% were male, 92% were married. Angiography was performed in 67% of the patients from the radial artery and 33% from the femoral artery. The average overall comfort score was found to be 3.03 ± 0.3. The patients received the highest score from psychospiritual comfort subscale and the lowest score from physical comfort subscale. The score averages of physical, psychospiritual, environmental, general comfort of the patients who underwent transradial PCI were statistically higher than transfemoral (p<0.05). According to both access methods, a significant difference was found between the mean scores of the levels of relief and ease. Conclusions: As a result, the general comfort level of the patients who underwent PCI was found above medium level. The patients received the lowest score from physical comfort subscale. The comfort level of the patients who underwent transradial method was found to be higher than those transfemoral.