i. Which of the following are included in your sepsis care bundle?
1. Obtain lactate level
2. Obtain blood cultures/other cultures (urine, CSF, wound, etc) before antimicrobial agent administration
3. Administer broad-spectrum antimicrobial agents within 1 hour of time of presentation (for inpatients) or within 3 hours of time of presentation (for ED patients)
4. Administer IV fluid challenge for hypotension or lactate ≥ 4 mmol/L
5. Administer vasopressor medications to maintain MAP ≥ 65 mmHg after IV fluid challenge and within 6 hours of time of presentation
6. Obtain a follow up lactate level if initial lactate was elevated (>2), to evaluate resuscitation interventions (Target is normalization of lactate level)
7. If persistent hypotension, after 1-hour from completion of the 30 mL/kg IV fluid challenge resuscitation or lactate ≥ 4 mmol/L, measure CVP and/or Scv02 levels (Target is CVP 8-12 mmHg, Scv02 of ≥70% -these targets are being debated based on recent trial results –ARISE, PROCESS, PROMISE)