Acknowledgements
N.J.G designed the experiments, performed the experiments, analysed the data and drafted the manuscript. S.P.W. and C.B. and contributed to the experimental work. S.G. and H.C.P. revised the manuscript critically for important intellectual content. S.A.G. contributed to the experimental work and revised the manuscript critically for important intellectual content. N.J.G., H.C.P. and S.G. contributed to the conception of the study, design of experiments, supervised the experimental work and revision of the manuscript critically for important intellectual content. All authors approved the manuscript.