Quercitrin inhibits thrombus formation on collagen-coated
surfaces under arteriolar shear
To assess the effects of quercitrin on in vitro thrombus
formation, a flow chamber assay was performed under arteriolar shear
(1,000 s−1). In this experiment, the amount of
quercitrin administrated was based on a previous finding.(Ma, Luo, Jiang
& Liu, 2016) Blood drawn from vehicle-treated mice exhibited widespread
coverage with densely packed platelet thrombi on collagen surfaces
(Figure 7A). Conversely, blood drawn from quercitrin-treated mice
displayed markedly reduced surface coverage (Figure 7B). Moreover, as
determined by confocal microscopy, the volume of quercitrin-treated
platelet thrombi was significantly lower than that of vehicle-treated
platelet thrombi (Figure 7C). These results indicate that the dietary
administration of quercitrin inhibits platelet adhesion and aggregation
on collagen-coated surfaces under arteriolar shear.