Quercitrin inhibits thrombus formation on collagen-coated surfaces under arteriolar shear
To assess the effects of quercitrin on in vitro thrombus formation, a flow chamber assay was performed under arteriolar shear (1,000 s−1). In this experiment, the amount of quercitrin administrated was based on a previous finding.(Ma, Luo, Jiang & Liu, 2016) Blood drawn from vehicle-treated mice exhibited widespread coverage with densely packed platelet thrombi on collagen surfaces (Figure 7A). Conversely, blood drawn from quercitrin-treated mice displayed markedly reduced surface coverage (Figure 7B). Moreover, as determined by confocal microscopy, the volume of quercitrin-treated platelet thrombi was significantly lower than that of vehicle-treated platelet thrombi (Figure 7C). These results indicate that the dietary administration of quercitrin inhibits platelet adhesion and aggregation on collagen-coated surfaces under arteriolar shear.