Quercitrin inhibits in vivo FeCl3-induced thrombus formation but not hemostasis.
Due to the potent inhibitory effect of quercitrin on platelet function, we further hypothesized that quercitrin possesses anti-thrombotic properties. The potential effect of quercitrin on platelet thrombus formation in vivo was investigated via FeCl3-induced carotid artery thrombi, and the time to arterial occlusion was monitored. Carotid occlusion in the control mice occurred at a mean of 7.68 ± 2.19 minutes, whereas in the administration of quercitrin extended the carotid occlusion time to 12.13 ± 3.49 (50 mg/kg, BW) or 14.65 ± 2.51 (100 mg/kg, BW) minutes (Figure 7D). We further examined whether the dietary administration of quercitrin influences hemostatic function. Tail bleeding times were measured by the cessation of bleeding after tail amputation. We observed no statistical differences in tail bleeding time between the quercitrin and control groups (Figure 7E). These results suggest that quercitrin inhibits arterial thrombosis but not hemostasis in vivo .