Quercitrin inhibits in vivo FeCl3-induced
thrombus formation but not hemostasis.
Due to the potent inhibitory effect of quercitrin on platelet function,
we further hypothesized that quercitrin possesses anti-thrombotic
properties. The potential effect of quercitrin on platelet thrombus
formation in vivo was investigated via
FeCl3-induced carotid artery thrombi, and the time to
arterial occlusion was monitored. Carotid occlusion in the control mice
occurred at a mean of 7.68 ± 2.19 minutes, whereas in the administration
of quercitrin extended the carotid occlusion time to 12.13 ± 3.49 (50
mg/kg, BW) or 14.65 ± 2.51 (100 mg/kg, BW) minutes (Figure 7D). We
further examined whether the dietary administration of quercitrin
influences hemostatic function. Tail bleeding times were measured by the
cessation of bleeding after tail amputation. We observed no statistical
differences in tail bleeding time between the quercitrin and control
groups (Figure 7E). These results suggest that quercitrin inhibits
arterial thrombosis but not hemostasis in vivo .