Discussion
We found co-occurrence of LTBi with DM to be associated with an
increased release of proinflammatory IL-6, IL-2 and TNF-α but reduced
SOCS3 mRNA levels. SOCS3 protects against MTB infection therefore,
reduced levels in DM-LTB may be contribute to progression from LTBi to
active TB in individuals infected with MTB.
Key words: MTB, latent TB, diabetes, SOCS3