Optimum dosage
Evidence from the treatment of past epidemics with PT, and the results
currently available indicate that the correct dose of convalescent
plasma to be administered may be variable depending on a different
indication, whether it is in prophylaxis or treatment. The reported
studies have used approximately (200 mL) units of plasma (19), however,
in the various clinical studies currently underway, therapeutic regimens
for post-exposure prophylaxis and therapeutic regimens for the treatment
of infection have been proposed. The duration of effectiveness of PT is
not known, but it is hypothesized that to last from weeks to a few
months (20) . For a patient of about 80 Kg, the standard dose to be used
for the treatment should be in dependence of the various supporting
studies, about 250 ml of plasma, in the pediatric population
(experiments are being planned), there will be a need for doses
according to body weight. However, there are currently levels of
uncertainty about the optimal dose.