Materials and Methods
Retrospective cohort of 167 consecutive patients who received an IE
diagnosis, according to Duke’s modified criteria, from January 2010 to
December 2015, in a Brazilian tertiary university hospital. There were
no exclusion criteria.
Primary endpoint was all-cause in-hospital mortality, defined as any
death occurred during the index hospitalization, regardless of hospital
length of stay. This outcome was analyzed according to the treatment
received, clinical vs. surgical. Data from medical records were
collected and reviewed by two independent reviewers. In case of
disagreement, a third review was performed.
Descriptive data were expressed as mean ± standard deviation (SD) or
median and interquartile range (Q1-Q3).
Statistical analyses were performed using the statistical package SPSS
(version 18.0; SPSS Inc, Chigaco, IL, USA). Categorical variables were
analyzed using Chi-square Test, while continuous variables were analyzed
using Student’s T-test or Mann-Whitney U test, according to the
distribution pattern. Logistic regression was used for univariate
analyses. Multivariate analysis model was proceeded to identify
independent predictors of mortality. A two-sided p -value lower
than 0.05 was considered significant for all analyses. This study was
reviewed and approved by the institution’s research ethics committee
(CAAE:40755515900005327).