Luminal Prucalopride
Luminal administration of prucalopride in the proximal human colon evoked powerful propulsive motor patterns and enhanced the amplitude of simultaneous pressure waves compared to both baseline and after meal. This response is similar to a typical response to luminal bisacodyl (37) (4). The induction of vomiting is a known effect of mucosal 5-HT receptor activation in the small bowel (48). The effect of prucalopride is likely mediated by 5-HT4Rs on enterochromaffin cells since we found an abundance of the 5-HT4R in the epithelial layer of biopsies of this patient and 100% co-localization of the receptor with 5-HT positive cells.