Crystal structures analysis
The crystal structure of human molybdopterin synthase complex (PDB ID:
5MPO, (Kopec, 2016) and molybdopterin synthase from Staphylococcus
aureus complexed with precursor Z (PDB ID: 2QIE, (Daniels, 2008) were
downloaded from the Protein Data Bank (Rose, 2017). Protein structures
were aligned and analyzed using PyMol software [PyMol Schrödinger
LLC]. The potential effects of substitutions at 158 and 159 positions
in the molybdopterin synthase catalytic subunit were examined by the
PredictSNP webserver (Bendl, 2014).