Introduction
This project aimed to determine what genetic mutations (resulting from
coding errors) could be responsible for the development of uveal
melanoma. Within this study, genetic alterations resulting from
chromosomal rearrangements were disregarded, but base pair mismatches
causing missense, nonsense, or frameshift mutations were considered.
Some patients had also experienced metastasis of cancerous cells through
the bloodstream; data from their sample genomes were considered
separately in an effort to identify any genetic mutations accelerating
metastasis. The basic procedures for this study involve the comparison
of a mutated DNA sequence (found in cancerous cells) with the matched
normal sequence (found in healthy, unaffected cells).