Future directions
Although the routine monitorings of the plasma concentrations of NOACs
and the anti-factor Xa activities are generally not necessary in the
daily practice, the plasma concentrations of NOACs haven been shown
significantly associated with bleeding and ischemic
events.54,55If the measurements of plama
concentrations of NOACs were available in the institutions caring the
COVID-19 infected patients, the monitoring of plasma levels of NOACs may
be considered when drug-drug interactions between NOACs and medications
for COVID-19 are concerned. More clinical experiences are necessary for
the concomitant use of OACs and COVID-19 therapies.