Soy
The cupins Gly m 5 and 6 were suggested as markers for severe allergic reactions in 30 soy-allergic European patients.270 A high diagnostic value of the 2S albumin Gly m 8 was reported in soybean-sensitized Japanese children with and without symptoms.271 Gly m 8 had an AUC=0.75 for soy allergy while the values for Gly m 5 and 6 were 0.69 and 0.64, respectively. In a study on soy allergy diagnostics, Gly m 8 had the highest AUC (0.79), comparable to skin prick test (0.76) and sIgE to soy extract (0.77).272 In this study, the cupins Gly m 5 and 6 were related to mild symptoms.