Results
We found that CoE originally appraised as VL/L had 2.1 (95%CI: 1.19 to 4.12; p=0.0091) times higher odds to be changed in the future studies than M/H CoE. However, the effect size was not different when CoE changed from VL/LM/H vs. M/HVL/L [ROR=1.02 (95%CI: 0.74 to 1.39) vs. 1.02 (95%CI: 0.44 to 2.37); p=1 for the between subgroup differences]. aROR was similar between the subgroups [median (IQR):1.12 (1.07 to 1.57) vs 1.21 (1.12 to 2.43)]. We observed large inconsistency (I2=99%) and imprecision in treatment effects (seR=1.09).