Characteristics of subjects
Patient characteristics are summarized in Table 1 (n=103). The median age was 13.5 years (range 1-24 years) at initial evaluation for IO; 60 (58%) were male. The most frequent cancer types were high-risk B-cell precursor acute lymphoblastic leukemia (HR-ALL; n=28, 27%), followed by acute myelogenous leukemia (AML; n=20, 19%). Sixty subjects received HSCT, including autologous transplant for solid tumors (n=22). At time of assessment, 73 were post-completion of treatment.