Statistical methods
Statistical analyses were conducted in JMP® Pro, Version 14.0.0 (SAS Institute Inc., Cary, NC, 2018) using a two-sided p-value of 0.05 for significance. Patient characteristics were reported as mean [range] for continuous variables and as frequency (percent) for categorical variables. Univariate analyses used Student’s t test or Wilcoxon non-parametric test for continuous variables, and Pearson’s χ2 test or Fisher’s exact test for dichotomous variables.