3.2 Nicorandil decreases patient blood pressure in a concentration-dependent manner
In this study, the intravenous pumping rate of Nicorandil was adjusted according to the patient’s blood pressure levels, and the effect of different concentrations of Nicorandil on the patient’s SBP and DBP was observed(Table 2). It was found that the systolic blood pressure of the patients can be significantly reduced compared with the baseline blood pressure when the pumping rate of Nicorandil at 4 mg/h and 6 mg/h, respectively (p < 0.01) ( Figure 1). And the reduction in systolic blood pressure was 18.00±18.01, 27.04±17.25 respectively. And compared with the baseline DBP,the levels of DBP decreased significantly when the pumping rate of Nicorandil were 4 mg/h and 6 mg/h (p < 0.01) (Figure 2). And the reduction in DBP was 8.71± 9.01 and 15.17±12.93, respectively. But when the pumping speed is 2 mg/h, there is no significant statistical changes compared with the baseline SBP and DBP. (p > 0.05) (Figure 1 and Figure 2 ). These showed that Nicorandil could decrease patients blood pressure in a concentration-dependent manner.