Fig 2. Mechanisms of action of tumour antigen-targeting
antibodies
Tumour antigen-targeting (tumour-depleting) antibodies mediate tumour
cell-killing via different mechanisms: (1,2) activation of immune
effector cells (ADCC, ADCP), (3) initiation of complement cascade (CDC),
(4) blocking important signalling pathways in tumour cells and (5)
formation of immune complexes inducing enhanced tumour antigen
cross-presentation by DCs, leading to adaptive immune response.