Figure 3 - A novel neutrophil subgroup in asthma
In humans, neutrophils released from the bone marrow that express low levels of CD16 and high levels of CD62L. This CD16dimCD62Lhigh subset is considered representing immature neutrophils whereas the CD16highCD62Ldim subset is thought to be mature and induces systemic inflammation. Also, their frequency increases in the blood after the bronchoprovocation test. In allergic asthmatics, neutrophils upregulate surface CD47 and simultaneously downregulate surface CD36 and CD43. The phagoptosis signals may play a role in prolonging neutrophil survival and asthma severity. CD62L; cluster of differentiation 62 Ligand.