Parameter 1st Tertile (n=16) 2nd Tertile (n=17) 3rd Tertile (n=16) P value
Demographic and Clinical Variables Demographic and Clinical Variables Demographic and Clinical Variables Demographic and Clinical Variables Demographic and Clinical Variables
Age (y) 48.4 ± 8.6 49.8 ± 8.0 52.6 ± 6.6 0.30
Gender (%Male) 81.3% 88.2% 75.0% 0.62
Body Surface Area (m2) 1.96 ± 0.18 1.91 ± 0.21 1.82 ± 0.18 0.21
Heart Rate (bpm) 92.25 ± 12.73 87.53 ± 15.40 90.94 ± 13.23 0.60
Systolic BP (mmHg) 111.77 ± 26.55 110.19 ± 14.45 110.64 ± 23.17 0.94
Diastolic BP (mmHg) 69.95 (28.75) 73.50 (10.50) 74.95 (11.75) 0.88
Type of Cardiomyopathy Ischemic Nonischemic 37.5% 62.5% 76.5% 37.5% 37.5% 62.5%
0.03
NYHA Class Advanced Class III Class IV 75.0% 25.0% 64.7% 35.3% 68.8% 31.3%
0.81
Rhythm on ECG Sinus Rhythm Atrial Fibrillation 56.3% 43.8% 82.4% 17.6% 75.0% 25.0%
0.24
Echocardiographic Parameters Echocardiographic Parameters Echocardiographic Parameters Echocardiographic Parameters Echocardiographic Parameters
Left Ventricular EDD (mm) 70.00 ± 7.65 67.82 ± 7.89 72.05 ± 8.86 0.34
Left Ventricular ESD (mm) 55.60 (10.21) 52.56 (8.13) 55.20 (6.00) 0.35
Left Ventricular EF (%) 20.00 (5.00) 20.00 (5.00) 20.00 (10.00) 0.58
Right Ventricular EDD (mm) 46.26 ± 5.54 40.26 ± 4.58* 34.50 ± 5.76†‡ <0.001
TAPSE (mm) 18.56 ± 3.44 18.71 ± 2.85 16.56 ± 3.69 0.14
TRV (m/s) 2.83 ± 0.47 3.14 ± 0.42 3.26 ± 0.47 0.03
Systolic Pulmonary Pressure (mmHg) 41.94 ± 11.29 51.00 ± 13.57 54.13 ± 14.49 0.03
Pressure/Dimension Index (mmHg/cm2) 1.94 ± 0.36 3.09 ± 0.34* 4.67 ± 1.39†‡ <0.001
Severity of TR Mild-Moderate Severe 81.3% 18.8% 94.1% 5.9% 87.5% 12.5%
0.52
Right Ventricular Failure by Visual Assessment (%) 31.3% 29.4% 43.8% 0.65
Laboratory Variables Laboratory Variables Laboratory Variables Laboratory Variables Laboratory Variables
Blood Urea Nitrogen (mg/dl) 23.28 ± 7.74 24.88 ± 4.82 24.11 ± 7.93 0.91
Creatinine (mg/dl) 0.94 ± 0.16 1.04 ± 0.31 0.86 ± 0.15 0.24
ALT (IU/L) 17.00 (34.00) 17.50 (31.50) 13.00 (20.50) 0.67
AST (IU/L) 19.00 (21.00) 17.50 (18.50) 16.00 (12.00) 0.91
Albumin (mg/dl) 3.90 ± 0.26 3.84 ± 0.54 3.88 ± 0.51 0.96