Statistical Analysis
The statistical software RStudio Team (version 1.2.5033 [2019], RStudio: Integrated Development for R. RStudio, Inc., Boston, MA URL:http://www.rstudio.com/) was used for statistical analysis. Categorical data were reported as frequency and percentage, and comparisons between groups were performed by chi-square or Fisher tests, as appropriate. Continuous variables were reported as the median and interquartile range, and the Mann-Whitney U test was used to assess differences between groups. Receiver-operating-characteristic (ROC) curves were generated and detection rates (DR) at fixed 5%, 10%, 15%, 20%, 25% and 30% false-positive rates (FPR) were calculated for both algorithms. The predictive accuracies of both algorithms were compared for a fixed FPR of 10% as well as for the resulting areas under the curve (AUC), which were compared by the Delong test20. The Bonferroni correction was used in all tests when multiple comparisons were assessed. Statistical significance level was set at p<0.05.