Age in years, median (IQR) |
31.5 (29-33) |
32 (28.5-37) |
32
(28-36) |
BMI in kg/m2, median (IQR) |
23.1 (21.9-24.5) |
23.1
(20.2-26.4) |
23.9 (21.4-27.6) |
Ethnicity |
|
|
|
White |
159 (94.6%) |
189 (93.6%) |
2196 (84.6%) |
Black |
4 (2.4%) |
6 (3.0%) |
70 (2.7%) |
Mixed |
5 (3.0%) |
5 (2.5%) |
209 (8.1%) |
Asian |
0 (0.0%) |
1 (0.5%) |
64 (2.5%) |
South-east Asian |
0 (0.0%) |
1 (0.5%) |
58 (2.2%) |
Smoking during pregnancy |
0 (0.0%) |
15 (34.1%)† |
283
(11.6%)§ |
ART |
|
|
|
Insemination |
2 (1.2%) |
3 (1.5%) |
16 (0.6%) |
IVF |
6 (3.6%) |
7 (3.5%) |
77 (3.0%) |
IVF with egg donation |
0 (0.0%) |
1 (2.3%) (% del total) |
22
(0.9%) |
Medical history |
|
|
|
Chronic Hypertension |
1 (12.5%)† |
2 (4.5%) |
27
(1.1%)‡ |
Diabetes mellitus |
0 (0.0%) |
2 (4.5%) |
32 (1.3%) |
Autoimmune disease |
1 (12.5%) |
2 (4.5%) |
101 (4.1%) |
APS |
0 (0.0%)† |
3 (6.8%) |
6 (0.2%)‡ |
Obstetric history |
|
|
|
Nulliparous |
5 (62.5%) |
20 (45.5%) |
1126 (46.2%) |
Previous preeclampsia |
1 (12.5%)† |
2 (4.5%) |
32
(1.3%)‡ |
Biophysical variables |
|
|
|
GA at the time of first trimester ultrasound scan in weeks, median (IQR) |
12.4 (12.1-12.6) |
12.4 (11.9-12.9) |
12.6 (12.1-13) |
MAP in mmHg, median (IQR) |
90.8 (85.2-96) |
86.7 (80-91.1) |
84.3
(78.3-90.7) |
MoM MAP, median (IQR) |
1.14 (1.04-1.17) |
1.07 (0.96-1.17) |
1.05
(0.97-1.15) |
Mean UtAPI, median (IQR) |
1.88 (1.74-2.67) |
1.94 (1.72-2.45)† |
1.68
(1.34-2.04)§ |
MoM UtAPI, median (IQR) |
1.12 (1.01-1.60) |
1.20 (1.02-1.47)† |
1.02
(0.84-1.25)§ |
Biochemical variables |
|
|
|
GA for PAPP-A + PlGF measurement median (IQR) |
11.4 (10.4-12.3) |
10.7
(10-11.8) |
10.6 (10-11.3) |
PAPP-A in mU/L, median (IQR) |
1801 (932.2-2456) |
964.25 (631.0-1794.5) |
1355 (816-2387) |
MoM PAPP-A, median (IQR) |
0.74 (0.6-0.89) |
0.73 (0.55-1.1)† |
1.06
(0.73-1.51)§ |
PlGF in pg/mL, median (IQR) |
20.0 (18.1-26.1)† |
28.2 (19.5-38.4) |
32.1 (24.1-43.0)‡ |
MoM PlGF, median (IQR) |
0.60 (0.42-0.79)† |
0.72 (0.61-0.97)† |
0.96
(0.75-1.18)‡§ |