Age in years, median (IQR) |
34 (32-37) |
35.5 (31-38)† |
32
(28-36)§ |
BMI in kg/m2, median (IQR) |
23.1 (22.5-32.1) |
24.0
(22.5-27.6) |
23.8 (21.3-27.5) |
Ethnicity |
|
|
|
White |
10 (90.9%) |
25 (83.3%) |
2209 (84.6%) |
Black |
0 (0.0%) |
1 (3.3%) |
71 (2.72%) |
Mixed |
1 (9.1%) |
2 (6.7%) |
209 (8.0%) |
Asian |
0 (0.0%) |
2 (6.7%) |
63 (2.41%) |
South-east Asian |
0 (0.0%) |
0 (0.0%) |
59 (2.26%) |
Smoking during pregnancy |
1 (9.1%) |
3 (10.0%) |
309
(11.8%) |
ART |
1 (9.1%) |
2 (6.7%) |
93 (3.6%) |
Insemination |
1 (9.1%) |
1 (3.3%) |
16 (0.6%) |
IVF |
0 (0.0%) |
1 (3.3%) |
77(2.95%) |
IVF with egg donation |
0 (0.0%) |
1 (3.3%) |
25
(0.96%) |
Medical history |
|
|
|
Chronic Hypertension |
3 (27.3%)† |
5 (16.7%)† |
24 (0.9%)
‡§ |
Diabetes mellitus |
0 (0.0%) |
1 (3.3%) |
35 (1.3%) |
Autoimmune disease |
0 (0.0%) |
3 (10.0%) |
105 (4.0%) |
APS |
0 (0.0%) |
1 (3.3%) |
8 (0.3%) |
Obstetric history |
|
|
|
Nulliparous |
2 (18.2%) |
13 (43.3%) |
1219 (46.7%) |
Previous preeclampsia |
2 (18.2%)† |
5 (16.7%)† |
30
(1.1%)‡§ |
Biophysical variables |
|
|
|
GA at the time of first-trimester ultrasound scan in weeks, median (IQR) |
12.7 (12.3-13.3) |
12.7 (12.3-13.3) |
12.6 (12.1-13) |
MAP in mmHg, median (IQR) |
96 (88.3-104.3)† |
91.2 (86.7-97.3)† |
84.3
(78.7-90.7)‡§ |
MoM MAP, median (IQR) |
1.14 (1.10-1.37)† |
1.14 (1.10-1.29)† |
1.06
(0.97-1.14)‡§ |
Mean UtAPI, median (IQR) |
2.25 (1.89-3.05)†§ |
1.91 (1.71-2.31)†‡ |
1.68 (1.34-2.05)‡§ |
MoM UtAPI, median (IQR) |
1.32 (1.12-2.13)† |
1.19 (1.01-1.44)† |
1.03
(0.84-1-26)‡§ |
Biochemical variables |
|
|
|
GA for PAPP-A + PlGF measurement, median (IQR) |
11.4 (9.9-12.3) |
10.9
(9.9-11.7) |
10.6 (10-11.3) |
PAPP-A in mU/L, median (IQR) |
1373 (607.3-2291) |
1158 (602.3-2291) |
1358 (823.2-2370) |
MoM PAPP-A, median (IQR) |
0.73 (0.6-0.93)† |
0.72 (0.57-1.05)† |
1.05
(0.73-1.5)‡§ |
PlGF in pg/mL, median (IQR) |
22.3 (19.0-29.8)† |
25.0 (19.3-31.7)† |
32.2 (24.3-43.0)‡§ |
MoM PlGF, median (IQR) |
0.69 (0.52-1.05)† |
0.78 (0.63-0.98)† |
0.96
(0.76-1.19)‡§ |