Main findings
This study shows that the Gaussian and FMF algorithms have similar predictive accuracies for PE and SGA, except for early-onset PE, where the FMF algorithm showed a significantly lower AUC with the combinations of MAP and PAPP-A, MAP and PlGF, and MAP alone. These significant differences could be partly attributed to the different methodology required for MAP assessment in both algorithms. In this study, MAP was measured once, in only one arm and after a 5-minute rest, while the FMF algorithm was designed with an average of two MAP measurements performed at 1-minute intervals in both arms simultaneously after a 5-minute rest21. This different methodology for MAP measurements may have affected the accuracy of all combinations including MAP in the FMF algorithm, but especially MAP alone or those combinations including MAP with one other factor.