ELISA
CB1R : results revealed a significant difference in CB1R
concentration, F (3,36) = 3.405, p = 0.028. Post hoc
comparisons revealed that MK+Sal (M = 868.171, SD = 187.744) had
significantly lower CB1R concentration than Ctrl+Sal (M = 1151.893, SD =
344.877), MD = 283.722, q = 2.531, p = 0.042, and MK+LowHU
(M = 1189.108, SD = 290.687), MD = 320.937, q = 2.864, p =
0.019. MK+Sal CB1R concentration was marginally less than MK+HighHU (M =
1127.731, SD = 111.976), MD = 259.560, q = 2.316, p =
0.068. In females, results revealed a significant difference in CB1R
concentration, F (3,16) = 5.404, p = 0.009. Post hoc
comparisons revealed that MK+Sal (M = 755.483, SD = 75.661) had
significantly lower CB1R concentration than Ctrl+Sal (M = 1188.093, SD =
299.908), MD = 432.610, q = 3.439, p = 0.009, and
MK+HighHU (M = 1197.826, SD = 54.206), MD = 442.343, q = 3.516,p = 0.008. MK+LowHU (M = 1017.288, SD = 244.288) trended towards
a greater CB1R concentration than MK+Sal, MD = 261.805, q =
2.081, p = 0.13 (See Figure 5).
5-HT1AR : Results revealed a significant difference in 5-HT1AR
concentration, F (3,36) = 12.893, p < 0.001. Post
hoc comparisons revealed that MK+Sal (M = 86.386, SD = 30.55) had
significantly lower CB1R concentration than Ctrl+Sal (M = 150.418, SD =
39.378), MD = 64.032, q = 4.963, p < 0.001,
MK+LowHU (M = 142.419, SD = 24.399), MD = 56.033, q = 4.343,p < 0.001, and MK+HighHU (M = 158.752, SD = 15.809), MD
= 72.366, q = 5.609, p < 0.001. In females, results
revealed a significant difference in 5-HT1AR concentration, F(3,16) =
158.263, p < 0.001. Post hoc comparisons revealed that
MK+Sal (M = 58.308, SD = 2.539) had significantly lower CB1R
concentration than Ctrl+Sal (M = 114.917, SD = 10.129), MD = 56.609,q = 13.560, p < 0.001, MK+LowHU (M = 120.154, SD
= 4.379), MD = 61.846, q = 14.815, p < 0.001,
and MK+HighHU (M = 146.577, SD = 6.785), MD = 88.269, q = 21.144,p < 0.001. In males, results revealed a significant
difference in 5-HT1AR concentration, F (3,16) = 32.858, p< 0.001. Post hoc comparisons revealed that MK+Sal (M =
114.464, SD = 11.073) had significantly lower CB1R concentration than
Ctrl+Sal (M = 185.919, SD = 15.347), MD = 71.456, q = 9.343,p < 0.001, MK+LowHU (M = 164.684, SD = 9.001), MD =
50.220, q = 6.567, p < 0.001, and MK+HighHU (M =
170.927, SD = 12.072), MD = 56.463, q = 7.383, p< 0.001 (See Figure 5).