MK-801 model of schizophrenia
The effect of MK-801 was tested as a model of schizophrenia. We assessed if MK-801 induced deficits consistent with schizophrenic-like behaviors and receptor sensitization. Mice were given saline (sal) or MK-801 (0.3mg/kg) for 7 days. Mice were then given MK-801 or saline and treatment (vehicle[veh], HU-580 0.01ug/kg, or HU-580 0.05 ug/kg) for 10 days. Behaviors were tested at one week and the end of the treatment phase.