Exhaled 15-HETE and thromboxin-B2 are associated with
therapeutic outcome in childhood asthma
Li-Chen Chen, MD1,2,3, Hsu-Min Tseng, PhD4, Ming-Ling Kuo, PhD1, 2,5,
Chih-Yung
Chiu, MD, PhD3,7,
Sui-Ling
Liao, MD 3,6,
Kuan-Wen
Su, MD 3,6,
Ming-Han
Tsai, MD, PhD 3,6,
Man-Chin
Hua, MD3,6,
Shen-Hao
Lai, MD 3,7,
Tsung-Chieh
Yao, MD 2,3,
Kuo-Wei
Yeh, MD2,3, Ai-Hsuan Wu, MS1,2,
Hsiu-Yueh Yu, MS1,2,
Jing-Long Huang, M.D1,2,3* and
Shau-Ku Huang,
PhD8,9*
1Department of Pediatrics, New Taipei Municipal
TuCheng Hospital, New Taipei, Taiwan, 2 Division of
Allergy, Asthma, and Rheumatology, Department of Pediatrics, Chang Gung
Memorial Hospital, Chang Gung University College of Medicine, Taoyuan,
Taiwan,; 3Community Medicine Research Center, Chang
Gung Memorial Hospital at Keelung, Keelung, Taiwan;4Department of Healthcare Management, Chang Gung
University, Taoyuan, Taiwan; 5Department of
Microbiology and Immunology, Graduate Institute of Basic Medical
Research, Chang Gung University, Taoyuan, Taiwan;6Department of Pediatrics, Chang Gung Memorial
Hospital at Keelung, Keelung, Taiwan; 7Division of
Pediatric Pulmonology, Department of Pediatrics, Chang Gung Memorial
Hospital, Taoyuan, Taiwan; 8National Institute of
Environmental Health Sciences, National Health Research Institutes,
Zhunan, Taiwan; 9Johns Hopkins Asthma and Allergy
Center, Johns Hopkins University School of Medicine, Baltimore, USA
Correspondence: Jing-Long Huang, Department of Pediatrics, Chang Gung
Memorial Hospital, Taoyuan, Taiwan, Email:hjlong0182@gmail.com; Shau-Ku
Huang, National Health Research Institutes, Zhunan, Taiwan. Email:skhuang1@gmail.com
* JLH and SKH contributed equally.
Funding information This work was supported, in part, by Chang Gung
Memorial Hospital (CMRPG3G2051, CMRPVVK0161)., the Ministry of Science
and Technology, Taiwan (MOST 108-2314-B-182A-088) and, in part, by a
grant from National Health Research Institutes, Taiwan (EO-109-PP-10).
CONFLICT OF INTEREST
The authors declare that they have no conflict of interests
AUTHOR CONTRIBUTIONS
It was the responsibility of Li-Chen Chen to conceive, organize, and
implement the research protocol, as well as to interpret the data, guide
discussions of the results, and draft the manuscript. Chih-Yung Chiu,
Sui-Ling Liao, Kuan-Wen Su, Ming-Han Tsai, Man-Chin Hua, ShenHao Lai,
Tsung-Chieh Yao, and Kuo-Wei Yeh were responsible for the recruitment of
study subjects and clinical data evaluation. AiHsuan Wu, Hsu-Min Tseng,
and Ming-Ling Kuo participated in the experiment and data analysis. With
regards to the corresponding authors, Jing-Long Huang coordinated the
study and interpreted the data, while Shau-Ku Huang supervised the
research program and contributed to the design and manuscript writing.
All authors had an opportunity to edit the manuscript and all approved
of its submission.