Large-for-gestational-age
Seventeen (11 plus 6) studies investigated the effects of LGA on cognitive or academic outcomes. Overall, LGA children had higher cognitive scores than AGA children (16 774 children; SMD, 0.06; 95% CI, 0.01 – 0.11; I2, 0%; low certainty evidence; Trim and Fill, 0.05, 0.01 – 0.10). The results are shown in Figure 3 b). Cognitive impairment was less common in LGA children than AGA children (417 562 children; OR, 0.94; 95% CI, 0.92 – 0.97; I2, 0%; low certainty evidence; Trim and Fill, 0.94, 0.91 – 0.97), as was low academic performance (775 745 children; OR, 0.93; 95% CI, 0.89 – 0.97; I2, 61%; low certainty evidence; Trim and Fill, 0.90, 0.86 – 0.95) (Figure 3b).