Author contributions
Q.Q.Z., J. S. and X. J. W. designed the study. X.Y.Y., J.F.L., Y.Z.W, M.M.L. and K.C. performed the experiments. X.Y.Y. and Q.Q.Z.wrote the manuscript. X. J. W. supervised the overall study. J. S. is the guarantor of this work; as such, Q.Q.Z.had full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the analysis.