Figure 2 Colitis can be improved by the administration of EGCG in mice. Except for the normal group, mice in other groups were given DSS (3% w/v) for 8 days and the mice were treated with or without EGCG, respectively. EGCG promotes recovery of DSS-induced colitis in mice. (A) Body weight change rate (the change rate of body weight in each group of mice was compared with the body weight in the same group of mice on the 1st day). (B, C) Length of the colon (from the appendix to the anus) were detected on day8. (D)The index of the spleen; (E) Disease activity index; (F) The DAI score on day8 between groups; (G) Histopathological images showing paraffin-embedded sections stained with H&E in the colon; (H)Histopathologic scoring of the inflammation, depth of inflammation and crypt damage. Scale bars, 200 μm. Data are presented as the means ± SEM. *P<0.05, **P<0.01, ***P<0.001 (one-way ANOVA). LE, Low dose of (-)-epigallocatechin gallate; HE, High dose of (-)-epigallocatechin gallate; DSS, Dextran sulfate sodium.