Methods
Pre- and post-vaccination sera from SARS-CoV-2 naïve healthy subjects
who received three doses of the mRNA vaccine (BioNTech, BNT) or the
inactivated vaccine (CoronaVac, CV) were used to monitor the level of
cross-reactive antibodies raised against other human coronaviruses by
enzyme-linked immunosorbent assay. In comparison, convalescent sera from
COVID-19 patients with or without prior vaccination history were also
tested. Pseudoparticle neutralization assay was performed to detect
neutralization antibody against MERS-CoV.