Fig 4. CXCR1 and CXCR2 mediate Th17 gene expression and recruitment of Th17 cells
(A ) Rorc mRNA expressions in the BALF cells after CDE challenge in CDE-SCM and CDE-MCM mice at 28 h post-CDE challenge. (B ) Il17 and Rorc mRNA expressions in the BALF cells in CDE-MCM at 28 h post-CDE challenge. (C ) Il17mRNA expressions in the lung in CDE-MCM at 28 h post-CDE challenge. (D-E ) The number of RorγT T-cells (D ) and IL17 secreting Th17 cells (E ) in the lung in CDE-MCM at 72 h post-CDE challenge.
BALF; bronchoalveolar lavage fluid
CDE; cat dander extract
CDE-MCM; CDE-multiple challenge model
RorγT; retinoic acid–related orphan receptor- gamma t
Th17; T helper 17