Fig 6. Ladarixin inhibits CDE-challenge induced lung DNA damage
(A-B ) CDE-MCM at 72 h post-CDE challenge. (A ) Representative gels showing PCR-amplified fragments encompassing mousepol β and β-globin in the lung, respectively. Amplification of a long fragment (LA, upper panels) was normalized to the corresponding short fragment of the same gene (SA, lower panels). Columns 1-7; mice challenged with CDE without the treatment of ladarixin. Column 8-13; mice challenged with CDE treated with ladarixin. (B ) The bar diagram represents the ratio of LA to SA amplification of each gene from two replicate gels.
CDE-MCM; CDE-multiple challenge model
LA; long amplicon
SA; short amplicon