Etiological survey of severe HFRS patients
The blood samples were detected for HTNV and other viruses. The antigen detection showed that 3 severe patients (No. 2, 5 and 6) were positive for HTNV. All other detection assay pertaining to SEOV and other common vector-borne infectious diseases were negative. DNA sequencing results confirmed the presence of HTNV (Appendix 2). To further confirm the pathogen, blood samples were subjected to virus isolation. Samples from two patients (No. 5 and 6) were psotive for SFTSV, and no other common vector-borne viruses were identified. DNA sequencing of the amplification product confirmed the presence of SFTSV (Appendix 3).